|Chemical Abstract Number (CAS #)||
||EPA Method 524.2|
Link to the National Library of Medicine's Hazardous Substances
Database for more details
on this compound.
|Use|| REACTION MEDIUM FOR METAL HYDRIDE REACTIONS; IN HISTOLOGICAL
IN SYNTHESIS OF BUTYROLACTONE, SUCCINIC ACID, 1,4-BUTANEDIOL
IN FABRICATION OF ARTICLES FOR PACKAGING, TRANSPORTING & STORING
SOLVENT FOR FAT OILS, UNVULCANIZED RUBBER; FOR MAKING ADIPIC ACID
As an indirect food additive, THF may be safely used as an adjuvant substance in the preparation
of resinous and polymeric coatings for polyolefin films. Used as the food contact surface of
articles intended for use in food processing.
SOLVENT FOR RESINS & PLASTICS-EG, POLYVINYL CHLORIDE
CHEM INT FOR POLYTETRAMETHYLENE GLYCOL
CHEM INT FOR TETRAHYDROTHIOPHENE
SOLVENT FOR COATING MAGNETIC TAPES & FOR CLEANING
AGENT IN LIQUID MEMBRANE ELECTRODE MFR
POLYMERIZATION SOLVENT-EG, FOR POLYISOPRENE
CHEM INT FOR ADIPONITRILE (FORMER USE)
Solvent in preparation of printing inks, adhesives, lacquers, and other coatings; Grignard reagent
in synthesis of motor fuels, vitamins, hormones, pharmaceuticals, synthetic perfumes,
organometallic compounds, and insecticides.
Solvent for top coating solutions, protective coatings, printing inks, etc
Solvent for production of tetraethyl and tetramethyl lead
Tetrahydrofuran is one of the typical phase change materials (PCMs) which is used for air
conditioning by its latent solar-heat storage power
Tetrahydrofuran can be used as a Lewis base to moderate the extreme reactivity of Sulfur trioxide
|Consumption Patterns|| Resin solvent 40%, Chemical Int 40%, Grignard reaction solvent 20%.
SOLVENT FOR RESINS, 40%; CHEMICAL INTERMEDIATE, 40%; REACTION
SOLVENT, 20% (1977)
Polytetrahydrofuran, 68%; coating solvent, 23%; other (reaction solvent, thiophane), 9% (1983)
|Apparent Color|| COLORLESS, MOBILE LIQUID
|Odor|| ETHER-LIKE ODOR ; FAINT FRUITY ODOR
|Boiling Point|| 66 DEG C @ 760 MM HG
|Melting Point|| -108.5 deg C
|Molecular Weight|| 72.11
|Density|| 0.8892 @ 20 DEG C/4 DEG C
|Odor Threshold Concentration|| 20-50 ppm
7.3-10.2 mg/cu m (recognition in air)
Low: 7.37 mg/cu m; High: 177.0 mg/cu m From table
|Sensitivity Data|| Strong irritant to skin & mucous membranes
Vapor: Irritating to eyes, nose and throat. Liquid: Irritating to skin and eyes.
|Environmental Impact|| Tetrahydrofuran, THF, is used in large (6.81x10 10 grams/yr) quantities as a chemical
intermediate and solvent (see also MANF). Because of its high vapor pressure and water
solubility, significant amounts of the THF used as solvents will be released to the environment and
workers will be exposed to it. Once released to the environment its behavior is not well
understood and very little monitoring data are available. In the atmosphere THF should degrade
rapidly (half-life - hours to days), especially under smog conditions and should be removed by
rain. THF in water may biodegrade (limited data) but will not be removed by photodegradation or
adsorption to sediment. Spills on soil are expected to evaporate rapidly or leach into groundwater.
THF is not expected to bioconcentrate in fish or other aquatic organisms.
|Environmental Fate|| TERRESTRIAL FATE: Tetrahydrofuran would be expected to volatilize from soil as well
as leach rapidly into the ground. Its biodegradation in soil is unknown.
AQUATIC FATE: Once released into water, the fate of THF is uncertain. Based on very limited
data, one would expect it to biodegrade (see also BIOD). It is stable toward photodegradation
and would not be expected to be adsorbed into the sediment. Its rate of evaporation is
ATMOSPHERIC FATE: THF released into the atmosphere will degrade by photochemical
reactions with hydroxyl radicals (see also ABIO). Data suggest that the half-life in the atmosphere
will range from hours to a few days (see also ABIO). A soluble chemical such as THF will be
expected to wash-out in rain.
|Drinking Water Impact|| 14 heavily industrialized river basins in US (201 sites), 29 sites (14%) >1 ppb, range
1-318 ppb .
EFFL: 30 samples taken between 1973-1976 ranged from 0 ug/l (Olin Corp, Brandenbury, KY,
Ohio River/Wabash River) to 450,000 ug/l (General Electric, Mt Vernon, IN, Ohio River). Other
notably high concn were 1000 ug/l (M/T Chem, Carrloton, KY, Ohio River), 850 ug/l (Olin Corp,
IN, Ohio River Wabash River), and 318 ug/l (Ashtabula, OH). |