SPECTRUM

Chemical Fact Sheet

Chemical Abstract Number (CAS #) 53963
CASRN 53-96-3
SynonymsAcetamidofluorene
2-Acetylaminofluorene
Acetamide, N-9H-fluoren-2-yl
2-AAF
Molecular FormulaC15H13NO

Link to the National Library of Medicine's Hazardous Substances
Database for more details on this compound.

Use Used in the study of liver enzymes and the carcinogenicity and mutagenicity of aromatic amines as a positive control It has been used as a research tool. However, this chemical induces tumors at multiple sites in several species, though not in the guinea pig, which is unable to metabolize it to an active intermediate. Much of our current knowledge of the nature of metabolic activation of chemical carcinogens is based on studies of this compound. Acetylaminofluorene is the type of chemical carcinogen most commonly investigated in research laboratories. It is potent and reproducibly carcinogenic.
Apparent Color Tan, crystalline solid
Melting Point 194 DEG C
Molecular Weight 223.26
Environmental Impact Release of 2-acetylaminofluorene to the environment from artificial sources is probably not significant since less than 20 lb/yr of this cmpd are consumed in the USA. If released to soil, 2-acetylaminofluorene is expected to have low mobilility. Chemical hydrolysis, oxidation and volatilization are not expected to be significant. If released to water, 2-acetylaminofluorene may undergo direct photolysis and is expected to strongly adsorb to suspended solids and sediments Chemical hydrolysis, oxidation, volatilization, and bioaccumulation are not expected to be significant. If released to the atmosphere, 2-acetylaminofluoren may undergo vapor phase adsorption to air borne particulate matter, it may reac with photochemically generated hydroxyl radicals (estimated vapor phase half-life= 5.92 hr) or it may undergo direct photolysis.
Environmental Fate TERRESTRIAL FATE: If released to soil, 2-acetylaminofluorene is expected to have low mobility. Chemical hydrolysis, oxidation, and volatilization are not expected to be significant. AQUATIC FATE: If released to water, 2-acetylaminofluorene may undergo direct photolysis due to absorption of UV light wavelengths >290 nm and is expected to strongly adsorb to suspended solids and sediments. Chemical hydrolysis, oxidation, bioaccumulation and volatilization are not expected to be significant. ATMOSPHERIC FATE: If released to the atmosphere, 2-acetylaminofluorene may undergo vapor phase adsorption to air-borne particulate matter, it may react with photochemically generated hydroxyl radicals (estimated vapor-phase half-life = 5.92 hr) or it may undergo direct photolysis.

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