| Chemical Abstract Number (CAS #) |
53963
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| Synonyms | Acetamidofluorene |
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2-Acetylaminofluorene | Acetamide, N-9H-fluoren-2-yl | 2-AAF |
| Molecular Formula | C15H13NO |
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| Use | Used in the study of liver enzymes and the carcinogenicity and mutagenicity of aromatic
amines as a positive control
It has been used as a research tool. However, this chemical induces tumors at multiple sites in
several species, though not in the guinea pig, which is unable to metabolize it to an active
intermediate. Much of our current knowledge of the nature of metabolic activation of chemical
carcinogens is based on studies of this compound. Acetylaminofluorene is the type of chemical
carcinogen most commonly investigated in research laboratories. It is potent and reproducibly
carcinogenic.
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| Apparent Color | Tan, crystalline solid
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| Melting Point | 194 DEG C
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| Molecular Weight | 223.26
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| Environmental Impact | Release of 2-acetylaminofluorene to the environment from artificial sources is probably
not significant since less than 20 lb/yr of this cmpd are consumed in the USA. If released to soil,
2-acetylaminofluorene is expected to have low mobilility. Chemical hydrolysis, oxidation and
volatilization are not expected to be significant. If released to water, 2-acetylaminofluorene may
undergo direct photolysis and is expected to strongly adsorb to suspended solids and sediments
Chemical hydrolysis, oxidation, volatilization, and bioaccumulation are not expected to be
significant. If released to the atmosphere, 2-acetylaminofluoren may undergo vapor phase
adsorption to air borne particulate matter, it may reac with photochemically generated hydroxyl
radicals (estimated vapor phase half-life= 5.92 hr) or it may undergo direct photolysis.
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| Environmental Fate | TERRESTRIAL FATE: If released to soil, 2-acetylaminofluorene is expected to have
low mobility. Chemical hydrolysis, oxidation, and volatilization are not expected to be significant.
AQUATIC FATE: If released to water, 2-acetylaminofluorene may undergo direct photolysis
due to absorption of UV light wavelengths >290 nm and is expected to strongly adsorb to
suspended solids and sediments. Chemical hydrolysis, oxidation, bioaccumulation and
volatilization are not expected to be significant.
ATMOSPHERIC FATE: If released to the atmosphere, 2-acetylaminofluorene may undergo
vapor phase adsorption to air-borne particulate matter, it may react with photochemically
generated hydroxyl radicals (estimated vapor-phase half-life = 5.92 hr) or it may undergo direct
photolysis.
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