Chemical Fact Sheet
|Chemical Abstract Number (CAS #)||
||EPA Method 8270 |
Link to the National Library of Medicine's Hazardous Substances
Database for more details
on this compound.
|Use|| RESEARCH CHEMICAL
Use: experimentally in cancer research
Used in research to induce specific forms of cytochrome p450 (MC1 and 2).
Methylcholanthrene synthesized and used in biochemical research.
|Apparent Color|| PALE YELLOW, SLENDER PRISMS FROM BENZENE PLUS ETHER
|Boiling Point|| 280 DEG C AT 80 MM HG
|Melting Point|| 179 DEG C
|Molecular Weight|| 268.34
|Density|| 1.28 AT 20 DEG C
|Sensitivity Data|| ON DIRECT CONTACT IT IS MODERATELY, & ON REPEATED EXPOSURE
|Environmental Impact|| Methylcholanthrene (MC) is not an environmental pollutant but is used in biochemical
research. If released to soil, it will adsorb very strongly to the soil and should not leach. It will not
hydrolyze, and/or biodegrade in soils and evaporation may occur depending on the carbon content
of soils. If released to water, MC will be expected to adsorb very strongly to sediments and to
bioconcentrate in aquatic organisms. It will not hydrolyze and will not be expected to significantly
biodegrade. Evaporation may be important; however, adsorption will limit this process. It may be
subject to direct photolysis in sunlight and may react with peroxyl radicals. If methylchloanthrene
is released to the atmosphere, it may be subject to direct photolysis; the estimated half-life in the
atmosphere is 2.81 hrs as a result of reaction with photochemically produced hydroxyl radicals.
Exposure to MC will be associated with its use in biochemical research.
|Environmental Fate|| TERRESTRIAL FATE: If methylcholanthrene (MC) is released to soil it will be
expected to adsorb very strongly to the soil and will not be expected to leach to the groundwater.
Very little data concerning the biodegradation of MC was located in the literature. Based on the
limited data located, MC may be subject to biodegradation in soils. MC will not be expected to
hydrolyze. Based on estimated evaporation rates from water, evaporation from soils may be an
important process, but adsorption will limit the rate.
AQUATIC FATE: If released to water, methylcholanthrene (MC) will be expected to adsorb
very strongly to sediments and to bioconcentrate in aquatic organisms. MC will not be expected
to hydrolyze, but evaporation may be an important process with an estimated half-life of 7.7 hr
predicted for evaporation from a river 1 m deep, flowing at 1 m/sec with a wind velocity of 3
m/sec. Adsorption to sediments and particulates will limit evaporation. MC will not be expected
to appreciably biodegrade based on the limited data located in the literature. MC may be subject
to direct photolysis to reaction with peroxyl radicals.
ATMOSPHERIC FATE: If methylcholanthrene is released to the atmosphere, it may be subject
to direct photolysis in sunlight. The estimated half-life of vapor phase methylcholanthrene in the
atmosphere is 2.81 hr as a result of reaction with photochemically produced hydroxyl radicals .
However, it should exist mostly adsorbed to particulate matter which should stabilize it to
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