SPECTRUM

Chemical Fact Sheet

Chemical Abstract Number (CAS #) 56531
CASRN 56-53-1
SynonymsDiethylstilbestrol
Stilbestrol
DES
alpha, alpha'-Diethylstilbenediol
Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis, (E)-
Molecular FormulaC18H20O2

Link to the National Library of Medicine's Hazardous Substances
Database for more details on this compound.

Use GROWTH PROMOTER FOR CATTLE & SHEEP; VETERINARY DRUG TO TREAT ESTROGEN DEFICIENCY DISORDERS. FORMER USES HUMAN MEDICINE DRUG FOR MENSTRUAL DISORDERS; DRUG FOR POST-PARTUM BREAST ENGORGEMENT; FOR CHEMOTHERAPY OF BREAST CANCER AND PROSTATE CANCER; POSTCOITAL CONTRACEPTIVE; DRUG FOR PREVENTION OF SPONTANEOUS ABORTIONS.
Apparent Color WHITE CRYSTALLINE POWDER; SMALL PLATES FROM BENZENE
Melting Point 169-172 DEG C
Molecular Weight 268.38
Environmental Impact Diethylstilbestrol (DES) may be released to the environment during transport, storage or disposal. If released to soil, diethylstilbestrol is predicted to strongly adsorb to the soil. Volatilization from the soil surface would probably not be significant. If released to water, diethylstilbestrol may bioconcentrate in aquatic organisms and strongly adsorb to suspended solids. If released to the atmosphere, DES vapor should rapidly oxidize primarily by reaction with ozone. The atmospheric half-life of diethylstilbestrol in the vapor phase at 298 deg K has been estimated to be 11.40 minutes.
Environmental Fate TERRESTRIAL FATE: If released to soil, diethylstilbestrol is predicted to strongly adsorb to the soil. Volatilization from the soil surface would probably be unlikely. The extent of biodegradation in soil is not known, although diethylstilbestrol has been shown to be resistant to degradation in activated sludge. AQUATIC FATE: If released to water, diethylstilbestrol may bioconcentrate in aquatic organisms and strongly adsorb to suspend solids and sediments. Diethylstilbestrol would not be susceptible to hydrolysis. The extent of biodegradation in natural waters is not certain, although diethylstilbestrol has been shown to be resistant to degradation in activated sludge. ATMOSPHERIC FATE: If released to the atmosphere, diethylstilbestrol vapors should rapidly oxidize, primarily by reaction with ozone . The atmospheric half-life of diethylstilbestrol in the vapor phase at 298 deg K has been estimated to be 11.40 minutes . Considering this relatively short half-life and the low water solubility of diethylstilbestrol (calculated to be 0.26 mg/l at 25 deg C(2,SRC)), wet deposition may not be significant.
Drinking Water Impact DRINKING WATER: German drinking water samples, 0.11-0.26 ng/l(1,2).

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