| Chemical Abstract Number (CAS #) |
56531
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| CASRN |
56-53-1 |
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| Synonyms | Diethylstilbestrol |
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Stilbestrol | DES | alpha, alpha'-Diethylstilbenediol | Phenol, 4,4'-(1,2-diethyl-1,2-ethenediyl)bis, (E)- |
| Molecular Formula | C18H20O2 |
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Link to the National Library of Medicine's Hazardous Substances
Database for more details
on this compound. |
| Use | GROWTH PROMOTER FOR CATTLE & SHEEP; VETERINARY DRUG TO TREAT
ESTROGEN DEFICIENCY DISORDERS. FORMER USES
HUMAN MEDICINE DRUG FOR MENSTRUAL DISORDERS; DRUG FOR
POST-PARTUM BREAST ENGORGEMENT; FOR CHEMOTHERAPY OF BREAST
CANCER AND PROSTATE CANCER; POSTCOITAL CONTRACEPTIVE; DRUG FOR
PREVENTION OF SPONTANEOUS ABORTIONS.
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| Apparent Color | WHITE CRYSTALLINE POWDER; SMALL PLATES FROM BENZENE
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| Melting Point | 169-172 DEG C
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| Molecular Weight | 268.38
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| Environmental Impact | Diethylstilbestrol (DES) may be released to the environment during transport, storage or
disposal. If released to soil, diethylstilbestrol is predicted to strongly adsorb to the soil.
Volatilization from the soil surface would probably not be significant. If released to water,
diethylstilbestrol may bioconcentrate in aquatic organisms and strongly adsorb to suspended
solids. If released to the atmosphere, DES vapor should rapidly oxidize primarily by reaction with
ozone. The atmospheric half-life of diethylstilbestrol in the vapor phase at 298 deg K has been
estimated to be 11.40 minutes.
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| Environmental Fate | TERRESTRIAL FATE: If released to soil, diethylstilbestrol is predicted to strongly
adsorb to the soil. Volatilization from the soil surface would probably be unlikely. The extent of
biodegradation in soil is not known, although diethylstilbestrol has been shown to be resistant to
degradation in activated sludge.
AQUATIC FATE: If released to water, diethylstilbestrol may bioconcentrate in aquatic
organisms and strongly adsorb to suspend solids and sediments. Diethylstilbestrol would not be
susceptible to hydrolysis. The extent of biodegradation in natural waters is not certain, although
diethylstilbestrol has been shown to be resistant to degradation in activated sludge.
ATMOSPHERIC FATE: If released to the atmosphere, diethylstilbestrol vapors should rapidly
oxidize, primarily by reaction with ozone . The atmospheric half-life of diethylstilbestrol in the
vapor phase at 298 deg K has been estimated to be 11.40 minutes . Considering this relatively
short half-life and the low water solubility of diethylstilbestrol (calculated to be 0.26 mg/l at 25
deg C(2,SRC)), wet deposition may not be significant.
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| Drinking Water Impact | DRINKING WATER: German drinking water samples, 0.11-0.26 ng/l(1,2).
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