| Chemical Abstract Number (CAS #) |
680319
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| Synonyms | Hexamethylphosphoramide |
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Phosphoric triamide, hexamethyl- | HMPA |
| Analytical Method |
EPA Method 8141A |
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| Molecular Formula | C6H18N3OP |
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| Use | PROCESSING SOLVENT FOR AROMATIC POLYAMIDE FIBER
DE-ICING ADDITIVE FOR JET FUELS; EXPERIMENTAL CHEMOSTERILANT FOR A
NUMBER OF INSECT PESTS; AS A CHEMICAL MUTAGEN
AS A SOLVENT FOR POLYMERS, AS A SELECTIVE SOLVENT FOR GASES, AS A
POLYMERIZATION CATALYST, AS A STABILIZER AGAINST THERMAL
DEGRADATION IN POLYSTYRENE, AS AN ADDITIVE TO POLYVINYL &
POLYOLEFIN RESINS TO PROTECT AGAINST DEGRADATION BY UV LIGHT, & AS A
SOLVENT IN ORG & ORGANOMETALLIC REACTIONS IN RESEARCH LAB
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| Apparent Color | COLORLESS, MOBILE LIQUID
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| Odor | AROMATIC ODOR; SPICY ODOR
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| Boiling Point | 233 DEG C @ 760 MM HG
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| Melting Point | FP: 5-7 DEG C
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| Molecular Weight | 179.24
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| Density | 1.03 @ 20 DEG C
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| Environmental Impact | Hexamethylphosphoramide may be released to the environment in waste streams
generated at sites of its commercial production and use as a UV inhibitor in plastics, a specialty
solvent, and as an experimental chemosterilant for insects. If released to soil or water, it may leach
readily in soils and sediments. No data are available on biodegradation of
hexamethylphosphoramide in soil or water. In water, hexamethylphosphoramide is not expected
to bioconcentrate in aquatic organisms or volatilize from aquatic systems. If released to the
atmosphere, hexamethylphosphoramide is expected to exist almost entirely in the vapor phase in
the ambient atmosphere. It will degrade relatively rapidly by reaction with photochemically
produced hydroxyl radicals (estimated half-life of 2 hr). Physical removal via wet deposition may
occur. Occupational exposure and exposure of the general public to hexamethylphosphoramide
occurs through dermal contact and inhalation of vapor.
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| Environmental Fate | TERRESTRIAL FATE: Based on an estimated Koc of 34(1,2,SRC),
hexamethylphosphoramide is expected to be very highly mobile in soil and may leach . Based
upon an estimated Henry's Law constant of 2X10-8 atm cu-m/mole at 25 deg C(1,2,4,SRC),
volatilization from moist soils is not expected to be an important fate process for
hexamethylphosphoramide.
AQUATIC FATE: Volatilization (based upon an estimated Henry's Law constant of 2X10-8 atm
cu-m/mole at 25 deg C(1,2,4,SRC)), bioconcentration (based upon an estimated BCF of
0.96(1,2,SRC)), and adsorption to sediment (based upon an estimated Koc of 34(1,2,SRC)) are
not expected to be important fate process of hexamethylphosphoramide in water.
ATMOSPHERIC FATE: Based upon a measured vapor pressure of 0.046 mm Hg at 25 deg
C , hexamethylphosphoramide is expected to exist almost entirely in the vapor-phase in the
ambient atmosphere . It is expected to degrade relatively rapidly in an average ambient
atmosphere (estimated half-life of about 2 hr) by reaction with photochemically produced
hydroxyl radicals . Since hexamethylphosphoramide is miscible in water , physical removal
via wet deposition is likely to occur.
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