SPECTRUM

Chemical Fact Sheet

Chemical Abstract Number (CAS #) 70304
CASRN 70-30-4
SynonymsHexachlorophene
Nabac
Phenol, 2,2'-methylenebis[3,4,6-trichloro-
Analytical Method
Molecular FormulaC13H6Cl6O2

Link to the National Library of Medicine's Hazardous Substances
Database for more details on this compound.

Use MEDICATION: TOPICAL ANTI-INFECTIVE; DETERGENT; (VET): ANTHELMINTIC (FLUKICIDE) ANTIBACTERIAL AGENT FOR SOAPS (EG, DEODORANT SOAPS), SURGICAL SCRUBS, NURSERIES, HOSPITAL EQUIPMENT, & COSMETICS; FUNGICIDE (EG, FOR VEGETABLES-EG, TOMATOES & PEPPERS), ORNAMENTALS BROAD-SPECTRUM FOLIAGE FUNGICIDE WITH CHEMOTHERAPEUTIC ACTION; PLANT BACTERICIDE; SOIL FUNGICIDE; ACARICIDE; USED ON CUCUMBERS FOR FUNGUS & BACTERIAL DISEASES; AS SOIL FUNGICIDE AGAINST RHIZOCTONIA, PREEMERGENCE & POSTEMERGENCE IN COTTON TO SUPPRESS BOLL ROT ON INANIMATE OBJECTS, IT IS A GOOD DISINFECTANT AGAINST FUNGI. Isobac discontinued in 1987 is a broad spectrum contact soil, foliar fungicide. Isobac Used as intrastate fungicide and miticide against spot anthracnose (scab, elsinoe), melanose (diaporthe), greasy spot (cercospora), and rust mites for foliar treatment of grapefruit, lemons, oranges, and tangerines; against spot anthracnose (scab, elsinoe), and melanose (diaporthe) for delayed dormant application of grapefruit, lemons, oranges, and tangerines. Hexaphene-LV Used as unclassified insecticide and miticide against lice and fleas on dogs and against animal pathogenic bacteria (g- and g vegetative) on dog sleeping quarters. Hilo Flea Powder with Rotenone and Dichlorophrene, Milo Flea Powder Used as bacteriostat, insecticide, and miticide against lice and fleas on cats and cat sleeping quarters. Hilo Cat Flea Powder Used as insecticide and miticide against ticks, fleas, and lice on cats. Enditch Pet Shampoo Used as insecticide, miticide, and bacteriostat against lice and fleas on dogs. Pedigree Dog Shampoo Bar Used as disinfectant, bacteriocide, and germicide against fungi on textiles, against animal pathogenic bacteria (g- and g vegetative), mold, and mildew on human clothing, and against mold and mildew on fabric surfaces. Blockade Anti Bacterial Finish Used as insecticide and miticide against ticks, lice, and fleas on dogs. B & B Flea Kontroller for Dogs Only For use as insecticide, miticide, repellent, or feeding depressant against lice, fleas, adult flies, adult gnats, and adult mosquitoes on dogs. Thera-Groom Pet Shampoo for Dogs for Veterinary Use Only Used as bacteristat against animal pathogenic bacteria (g- and g vegetative) on swimming pool surfaces, tires, eating establishment equipment and food contact surfaces, industrial premises and equipment, institutional premises and equipment, and bathroom premises. Brevity Blue Liquid Sanitizing Scouring Cream, Brevity Blue Liquid Bacteriostat Scouring Cream Used as a disinfectant, bacteriocide, and germicide against animal pathogenic bacteria (g- and g vegetative) and fungi, Pseudomonas species, Mycobacterium species (tubercle bacilli), and lipophilic viruses on livestock equipment and premises (enclosed premise treatment), hog farrowing pen premises (enclosed premise treatment), foaling pen premises for horses, unspecified farm premises and equipment, and poultry processing plant premises. En-Viron D Concentrated Phenolic Disinfectant Used as disinfectant, bacteriocide, germicide, and fungicide against animal pathogenic bacteria (g and g- vegetative) and fungi and Pseudomonas sp on sickroom content, sickroom equipment and premises, hospital premises, surgical instruments, dental instruments, hospital instruments, and hospital critical rubber and plastic items. Staphene O /IT IS SOMETIMES USED IN TREATMENT OF ACNE VULGARIS TO SUPPRESS ASSOCIATED STAPHYLOCOCCI. SRP: FORMER USE
Apparent Color NEEDLES FROM BENZENE ; WHITE TO LIGHT TAN, CRYSTALLINE POWDER
Odor ODORLESS OR HAS ONLY SLIGHTLY PHENOLIC ODOR
Melting Point 164 DEG C
Molecular Weight 406.92
Environmental Impact Release of hexachlorophene (HCP) to the environment may occur as a result of its production and use in germicidal soaps and other soaps and cosmetics. The monosodium salt has also found use as a broad-spectrum soil fumigant and seed-treatment fungicide. HCP's use has been restricted by the USFDA in 1972 to levels of less than or equal to 0.1%, and its use has been approved by the FDA for surgical scrubbing and handwashing in cases of outbreak of certain infections. If released to the soil HCP will adsorb very strongly to the soil and will not be expected to leach to the groundwater, to undergo hydrolysis or to significantly evaporate from soils or other surfaces. No information was found on biodegradation in soils. If released to water HCP will be expected to adsorb very strongly to sediments and may bioconcentrate in aquatic organisms. It will not hydrolyze and will not be expected to significantly evaporate from water. It may be subject to slow photodegradation in water based on its absorption of light above 290 nm. No information was found on biodegradation in surface waters. Half-life for biodegradation of HCP in river sediments was 290 days. Based on a comparison of rates of the degradation of 2,4,5-trichlorophenol in river sediments and in water, biodegradation of HCP in surface waters is expected to be slow. If HCP is released to the atmosphere it will be expected to be mainly in the particle-sorbed state due to its expected low vapor pressure and high estimated Koc. Dry deposition is expected to be the primary physical removal process. It may be subject to slow photodegradation in water based on its absorption of light above 290 nm. The estimated vapor phase half-life in the atmosphere is 2.47 days as a result of ring addition of photochemically produced hydroxyl radicals. Exposure to HCP will occur mainly through the dermal contact with consumer products which contain it, through occupational exposure related to its use as a broad-specturm soil fumigant and seed-treatment fungicide, and in surgical scrubbing and handwashing in cases of outbreak of certain infections. Minor exposure may result from the ingestion of contaminated drinking water.
Environmental Fate TERRESTRIAL FATE: If released to the soil hexachlorophene will adsorb very strongly to the soil and will not be expected to leach to the groundwater. It is not expected to undergo hydrolysis or significant evaporation from the surface of soils. It may be subject to slow photodegradation on the surface of soils based on its absorption of light above 290 nm. No information was found on biodegradation in soils. AQUATIC FATE: If released to water hexachlorophene (HCP) will be expected to adsorb very strongly to sediments and may bioconcentrate in aquatic organisms based on an estimated BCF of 317,000. It will not hydrolyze and will not be expected to significantly evaporate from water. It may be subject to slow photodegradation in water based on its absorption of light above 290 nm. No information on biodegradation in soils or surface waters was found. Half-life for biodegradation of HCP in Skidaway River, GA, sediments was 290 days . Based on comparison rates of the degradation of 2,4,5-trichlorophenol in river sediments and in water, biodegradation of hexachlorophene in surface waters is expected to be slow(1,SRC). ATMOSPHERIC FATE: If hexachlorophene is released to the atmosphere it is expected to be mainly in the particle-sorbed state due to its expected low vapor pressure and high estimated Koc. Dry deposition is expected to be the primary physical removal process. It may be subject to slow photodegradation in water based on its absorption of light above 290 nm (see also ABIO). The estimated vapor phase half-life in the atmosphere is 2.47 days as a result of ring addition of photochemically produced hydroxyl radicals.
Drinking Water Impact DRINKING WATER: HEXACHLOROPHENE HAS BEEN FOUND IN 2 SAMPLES OF FINISHED DRINKING WATER IN UPSTREAM & DOWNSTREAM WATER FROM 2 SEWAGE TREATMENT PLANTS, AT LEVELS OF 3.2 TO 24 UG/L & 16.4 TO 44.3 UG/L, RESPECTIVELY . DRINKING WATER: Corvallis, OR, May, 1979, 0.01 ppb (duplicate analysis) . Identified, not quantified in 2 finished drinking water samples . SURFACE WATER: Urban drainage area, Greensboro, NC, 1973, 7 sites, 100% pos, 3 sites upstream from 2 wastewater treatment plants, 9 samples, 100% pos, 4.0-24.8 ppb, avg 7.9 ppb, 1 site downstream from 1 treatment plant, 4 samples, 100% pos, 4.8-14.0 ppb, avg 8.8 ppb, 1 site downstream from both plants, surface water, 15 samples, 100% pos, 18.0-44.3 ppb, 29.1 ppb, bottom water, 12 samples, 100% pos, 15.2-48.3 ppb, avg 25.4 ppb, 2 sites further downsteam from both plants (sampled to determine the effects of dilution), 4 samples each, 100% pos, ranges, 5.2-14.8 and 3.2-8.0 ppb, avgs, 10.4 and 6.4 ppb . EFFL: HEXACHLOROPHENE HAS BEEN FOUND IN INFLUENT & EFFLUENT WATER OF 3 SEWAGE PLANTS AT LEVELS OF 20-31 & 6-12 UG/L, RESPECTIVELY . Corvallis, OR, sewage treatment plant, 7 consecutive days, Sept 1969, influent, 366-707 g/24 hrs, avg 524 g/24 hrs, effluent, 92.2-175 g/24 hrs, avg 138 g/24 hrs; Corvallis, Eugene, and Salem, OR, respectively, 24-hr composite samples, concn, ppb: influent, 30.8, 20.0, 30.0, effluent, 12.2, 5.6, 12.1, output, g/24 hr, 245, 244, 973, output, g/10,000 population, 24 hrs, 66.5, 44.0, 12.0 .

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