SPECTRUM

Chemical Fact Sheet

Chemical Abstract Number (CAS #) 74895
CASRN 74-89-5
SynonymsMethylamine
Aminomethane, Monomethylamine ,Carbinamine,Mercuralin, Methanamine, MMA
Apparent ColorCOLORLESS GAS OR LIQUID
OdorSTRONG AMMONIACAL ODOR
Boiling Point -6.3 DEG C @ 760 MM HG
Melting Point -93.5 DEG C
Molecular Weight 31.07
Density 0.699 @ -10.8 DEG C/4 DEG C
Sensitivity Data
Analytical Method EPA Method 8260
Molecular FormulaCH3NH3/SUB>

Link to the National Library of Medicine's Hazardous Substances
Database for more details on this compound.

UseCHEM INT FOR: WATER GEL EXPLOSIVES, 49.2%; FOR PESTICIDES, 24.6%; FOR N-METHYLPYRROLIDONE, 11.5%; FOR METHYLALKANOLAMINES, 6.6%; FOR N-METHYLTAURINE SURFACTANTS, 4.9%; FOR PHARMACEUTICALS; 1.6%; FOR OTHER CHEMICALS (EG, PHOTOGRAPHIC DEVELOPER), 1.6% (1982) MMFG: REACTION OF AMMONIA & METHYL ALCOHOL AT ELEVATED TEMPERATURE & PRESSURE IN THE PRESENCE OF A SILICA-ALUMINA CATALYST; REDUCTIVE AMINATION OF FORMALDEHYDE (FORMER METHOD) * ... BY HEATING METHYL ALCOHOL, AMMONIUM CHLORIDE, & ZINC CHLORIDE TO ABOUT 300 DEG C; BY HEATING AMMONIUM CHLORIDE & FORMALDEHYDE; MARVEL, JENKINS, ORG SYN 3, 67 (1923). * FORM: MARKETED IN LIQUEFIED FORM OR AS A 33% AQ SOLUTION. PATENTS: SMITH, US PATENT 2,456,599 (1948 TO COMM SOLVENTS). * GRADES: TECHNICAL (ANHYDROUS; 30-40% SOLN). * Grades of purity: Anhydrous, 99.3+%; water solutions, 30-50% by wt * MFS: AIR PRODUCTS & CHEMS, INC, INDUST CHEMS DIV, PENSACOLA, FL 32592 * EI DU PONT DE NEMOURS & CO, INC, CHEMS & PIGMENTS DEPT, BELLE, WV 25015 * GAF CORP, CHEM PRODUCTS, CALVERT CITY, KY 42029 * INTERNATIONAL MINERALS & CHEM CORP, IMC CHEM GROUP, INDUST CHEMS DIV, TERRE HAUTE, IN 47808 * Union Carbide Corp, Linde Div, 100 Davidson Ave, PO Box 44, Somerset, NJ 08873 (201) 356-8000 * [R1] Kem Chemical Corp, 542 S Fulton Ave, Mt Vernon, NY 10550 (914) 699-3110 * [R1] OMIN: CHEMICAL OXIDATION OF METHYLAMINE IN AQUEOUS SOLN OR IN METHANOL LEADS TO THE FORMATION OF SIGNIFICANT AMOUNTS OF AZOXYMETHANE, A STRONG CARCINOGEN IN RODENTS. * [R2] TREATMENT OF METHYLAMINE IN AQ SOLN WITH ETHYLENE OXIDE RESULTED IN THE FORMATION OF METHYLAMINOETHANOL. THE POSSIBILITY OF THE FORMATION OF CARCINOGENS FROM CARCINOGENIC PRECURSORS WHEN ETHYLENE OXIDE IS USED AS A FUMIGANT IS DISCUSSED. * [R3] USE: USED IN ORGANIC SYNTHESIS; TANNING * INTERMEDIATE FOR ACCELERATORS, DYES, PHARMACEUTICALS, INSECTICIDES, SURFACE ACTIVE AGENTS, TANNING, FUNGICIDES; DYEING OF ACETATE TEXTILES; FUEL ADDITIVE; POLYMERIZATION INHIBITOR; COMPONENT OF PAINT REMOVERS; SOLVENT; PHOTOGRAPHIC DEVELOPER; ROCKET PROPELLANT * CHEM INT FOR MONOMETHYLAMINE NITRATE WATER GEL EXPLOSIVES, METHYL ISOCYANATE, A PESTICIDE INT, N-METHYLPYRROLIDONE, METHYLALKANOLAMINES, N-METHYLTAURINE SURFACTANTS, PHARMACEUTICALS-EG, PHENSUXIMIDE, PHOTOGRAPHIC DEVELOPER, DIALKYLMETHYLAMINES * It has possible uses in solvent extraction systems in the extraction of aromatics from aliphatic hydrocarbons. * CPAT: CHEM INT FOR: WATER GEL EXPLOSIVES, 49.2%; FOR PESTICIDES, 24.6%; FOR N-METHYLPYRROLIDONE, 11.5%; FOR METHYLALKANOLAMINES, 6.6%; FOR N-METHYLTAURINE SURFACTANTS, 4.9%; FOR PHARMACEUTICALS; 1.6%; FOR OTHER CHEMICALS (EG, PHOTOGRAPHIC DEVELOPER), 1.6% (1982) * CHEMICAL PROFILE: Methylamines. Mono: explosives, 28%; insecticides, 25%; N-methyl pyrrolidone, 25%; other, 22%. * [R4] CHEMICAL PROFILE: Methylamines. Demand: 1987: 190 million lb; 1988: 195 million lb; 1992 /projected/: 205 million lb (Foreign trade is small). /Methylamines/ * [R4] PROD: (1978) 2.42X10+10 G * (1982) 1.90X10+10 G * (1981) 48,106X10+3 lb * (1985) 2.37X10+10 g * [R5] IMPT: (1978) ND * (1982) ND * EXPT: (1978) 9.09X10+9 G (INCL DI & TRIMETHYLAMINES) * (1982) 5.82X10+9 G (INCL DI & TRIMETHYLAMINES) * COFO: COLORLESS GAS OR LIQUID * ODOR: STRONG AMMONIACAL ODOR * BP: -6.3 DEG C @ 760 MM HG * MP: -93.5 DEG C * MW: 31.07 * CORR: Corrosive to copper, copper alloys, zinc alloys, aluminum, and galvanized surfaces * CTP: Critical temp: 156.9 deg C; critical pressure: 40.2 atm * DEN: 0.699 @ -10.8 DEG C/4 DEG C * DSC: pKa= 10.657; Ka= 2.70X10-11 at 25 deg C *; pKb= 3.35 *; pKb= 3.32; pKa= 10.68 * HTC: 253.5 kg cal/g mol wt at 25 deg C (liquid) * HTV: 6469.5 gcal/gmole * OWPC: log Kow= -0.57 * PH: STRONGER BASE THAN AMMONIA * SOL: 1 VOL OF WATER @ 12.5 DEG C DISSOLVES 1154 VOL OF GAS, @ 25 DEG C DISSOLVES 959 VOL OF GAS; 10.5 G IS CONTAINED IN 100 ML SATURATED BENZENE SOLN *; SOL IN ALCOHOL, BENZENE, WATER, ETHER, ACETONE *; 271 cc/cc aniline at 1 atm and 20 deg C *; 89 cc/cc anisole at 1 atm and 20 deg C *; 314 cc/cc benzyl alc at 1 atm and 20 deg C *; 298 cc/cc iso-butanol at 1 atm and 20 deg C *; 303 cc/cc n-butanol at 1 atm and 20 deg C *; 34 cc/cc cedrene at 1 atm and 20 deg C *; 52 cc/cc alpha-chloronaphthalene at 1 atm and 20 deg C *; 48 cc/cc cymene at 1 atm and 20 deg C 24 cc/1 cc decahydronaphthalene at 1 atm and 20 deg C *; 24 cc/cc decahydronaphthalene at 1 atm and 20 deg C *; 420 cc/cc diacetone alc at 1 atm and 20 deg C *; 115 cc/cc dibenzylether at 1 atm and 20 deg C *; 64 cc/cc o-dichlorobenzene at 1 atm and 20 deg C *; 313 cc/cc diethanolamine at 1 atm and 20 deg C *; 60 cc/cc diethylaniline at 1 atm and 20 deg C *; 336 cc/cc diethylene glycol mono-ethyl ether at 1 atm and 20 deg C *; 64 cc/cc dimethylaniline at 1 atm and 20 deg C *; 67 cc/cc dimethylcyclohexylamine at 1 atm and 20 deg C *; 132 cc/cc dimethylformamide at 1 atm and 20 deg C *; 440 cc/cc ethanol at 1 atm and 20 deg C *; 630 cc/cc ethylene glycol at 1 atm and 20 deg C *; 413 cc/cc furfuryl alc at 1 atm and 20 deg C *; 654 cc/1 cc methanol at 1 atm and 20 deg C *; 219 cc/1 cc methylcyclohexanol at 1 atm and 20 deg C *; 216 cc/cc monoethanolamine at 1 atm and 20 deg C *; 113 cc/cc monoethylaniline at 1 atm and 20 deg C *; 197 cc/cc monomethylaniline at 1 atm and 20 deg C *; 255 cc/cc morpholine at 1 atm and 20 deg C *; 88 cc/cc nitrobenzene at 1 atm and 20 deg C *; 86 cc/cc o-nitrotoluene at 1 atm and 20 deg C *; 34 cc/cc pinene at 1 atm and 20 deg C *; 339 cc/cc n-propanol at 1 atm and 20 deg C *; 92 cc/cc quinoline at 1 atm and 20 deg C *; 40 cc/cc tetrahydronaphthalene at 1 atm and 20 deg C *; 88 cc/cc o-toluidine at 1 atm and 20 deg C *; 316 cc/cc triethylene glycol at 1 atm and 20 deg C *; 480 cc/cc trimethylene glycol at 1 atm and 20 deg C * SPEC: MAX ABSORPTION (GAS): 190.5 NM (LOG E= 3.51); 215 NM (LOG E= 2.77) *; IR: 1651 (Documentation of Molecular Spectroscopy Collection) *; MASS: 6 (Atlas of Mass Spectral Data, John Wiley & Sons, New York) * SURF: 22.2 dynes/cm in contact with nitrogen at -12 deg C; 23.0 dynes/cm in contact with vapor at -20 deg C; 29.2 dynes.cm in contact with nitrogen at -70 deg C * VAP: 400 mm Hg at -19.7 deg C * OCPP: CONVERSION UNITS: 783 PPM= 1 MG/L; 1.27 MG/CU M= 1 PPM * FUMING LIQ WHEN LIQUEFIED BY COOLING IN ICE AND SALT MIXTURE * Heat of fusion: 47.20 cal/g= 197.48 J/g= 6,133 J/mol * Ratio of specific heats of vapor (gas): 1.1946 * Saturated liquid density: 43.260 lb/cu ft; liquid heat capacity: 0.803 Btu/lb-F; liquid thermal conductivity: 1.516 Btu-inch/hr-sq ft-F; liquid viscosity: 0.250 Centipoise (all at 20 deg F) * Saturated vapor pressure: 38.150 lb/sq in; saturated vapor density: 0.21270 lb/cu ft (all at 60 deg F) * Ideal gas heat capacity: 0.395 Btu/lb-F at 75 deg F * Amines tends to be fat soluble /Amines/ * DOT: Fire or Explosion: Extremely flammable; may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion hazard indoors, outdoors or in sewers. /Methylamine, anhydrous/ * Health Hazards: If inhaled, may be harmful. Vapor extremely irritating; contact causes burns to skin and eyes. Contact with liquid may cause frostbite. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. /Methylamine, anhydrous/ * Emergency Action: Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Self-contained breathing apparatus (SCBA) and structural firefighter's protective clothing will provide limited protection. Evacuate the leak or spill area immediately for at least 50 feet in all directions. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. CALL CHEMTREC AT 1-800-424-9300 FOR EMERGENCY ASSISTANCE. If water pollution occurs, notify the appropriate authorities. /Methylamine, anhydrous/ * Fire: Let tank car, tank truck or storage tank burn unless leak can be stopped; with smaller tanks or cylinders, extinguish/isolate from other flammables. Small Fires: Dry chemical, CO2 or Halon. Large Fires: Water spray, fog or standard foam is recommended. Move container from fire area if you can do it without risk. Cool containers that are exposed to flames with water from the side until well after fire is out. Stay away from ends of tanks. For massive fire in cargo area, use unmanned hose holder or monitor nozzles; if this is impossible, withdraw from area and let fire burn. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. /Methylamine, anhydrous/ * Spill or Leak: Shut off ignition sources; no flares, smoking or flames in hazard area. Stop leak if you can do it without risk. Use water spray to reduce vapors; isolate area until gas has dispersed. /Methylamine, anhydrous/ * First Aid: Move victim to fresh air and call emergency medical care; if not breathing, give artificial respiration; if breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Keep victim quiet and maintain normal body temperature. /Methylamine, anhydrous/ * Fire or Explosion: Flammable/combustible material; may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. /Methylamine, aqueous solution/ * Health Hazards: Poisonous if swallowed. If inhaled, may be harmful. Contact may cause burns to skin and eyes. Fire may produce irritating or poisonous gases. Runoff from fire control or dilution water may cause pollution. /Methylamine, aqueous solution/ * Emergency Action: Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Self-contained breathing apparatus (SCBA) and structural firefighter's protective clothing will provide limited protection. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire. CALL CHEMTREC AT 1-800-424-9300 FOR EMERGENCY ASSISTANCE. If water pollution occurs, notify the appropriate authorities. /Methylamine, aqueous solution/ * Fire: Small Fires: Dry chemical, CO2, Halon, water spray or standard foam. Large Fires: Water spray, fog or standard foam is recommended. Move container from fire area if you can do it without risk. Cool containers that are exposed to flames with water from the side until well after fire is out. Stay away from ends of tanks. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. /Methylamine, aqueous solution/ * Spill or Leak: Shut off ignition sources; no flares, smoking or flames in hazard area. Do not touch spilled material; stop leak if you can do it without risk. Water spray may reduce vapor; but it may not prevent ignition in closed spaces. Small Spills: Take up with sand or other noncombustible absorbent material and place into containers for later disposal. Large Spills: Dike far ahead of liquid spill for later disposal. /Methylamine, aqueous solution/ * First Aid: Move victim to fresh air and call emergency medical care; if not breathing, give artificial respiration; if breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case of contact with material, immediately flush skin or eyes with running water for at least 15 minutes. Keep victim quiet and maintain normal body temperature. /Methylamine, aqueous solution/ * Initial Isolation & Evacuation Distances: For a spill or leak from a drum or small container (or small leak from tank): Isolate in all directions 150 feet. For a large spill from a tank (or from many containers or drums): First isolate in all directions 300 feet; then, evacuate in a downwind direction 0.4 miles wide and 0.8 miles long. /Methylamine, anhydrous/ * FPOT: FLAMMABLE GAS AT ORDINARY TEMP AND PRESSURE. * LIQ SOLN ARE FLAMMABLE. /METHYLAMINES/ * NFPA: HEALTH: 3. 3= MATERIALS EXTREMELY HAZARDOUS TO HEALTH BUT AREAS MAY BE ENTERED WITH EXTREME CARE. FULL PROTECTIVE CLOTHING INCL SELF-CONTAINED BREATHING APPARATUS, COAT, PANTS, GLOVES, BOOTS, & BANDS AROUND LEGS, ARMS & WAIST SHOULD BE PROVIDED. NO SKIN SURFACE SHOULD BE EXPOSED. * FLAMMABILITY: 4. 4= VERY FLAMMABLE GASES OR VERY VOLATILE FLAMMABLE LIQ. SHUT OFF FLOW & KEEP COOLING WATER STREAMS ON EXPOSED TANKS OR CONTAINERS. * REACTIVITY: 0. 0= MATERIALS WHICH (IN THEMSELVES) ARE NORMALLY STABLE EVEN UNDER FIRE EXPOSURE CONDITIONS & ... ARE NOT REACTIVE WITH WATER. NORMAL FIRE FIGHTING PROCEDURES MAY BE USED. * FLMT: 4.9-20.7% * FLPT: 32 DEG F (CLOSED CUP) * AUTO: 430 deg C * FIRP: STOP FLOW OF GAS. USE WATER TO KEEP FIRE-EXPOSED CONTAINERS COOL & TO PROTECT ... /PERSONS/ EFFECTING THE SHUT-OFF. WATER SPRAY, CARBON DIOXIDE, DRY CHEM, &/OR "ALCOHOL" FOAM CAN BE USED ON FIRES INVOLVING WATER SOLN OF THE METHYLAMINES. /METHYLAMINES/ * If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Methylamine, anhydrous/ * The following types of respirators should be selected under the prescribed concentrations: 100 ppm: Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece. Any chemical cartridge respirator with a full facepiece and cartridge(s) providing protection against the compound of concern. Any air-purifying full facepiece respirator (gas mask) with a chin-style or front- or back-mounted canister providing protection against the compound of concern. Any powered air-purifying respirator with cartridge(s) providing protection against the compound of concern. Emergency or planned entry in unknown concentration or IDLH conditions: Any self-contained breathing apparatus with a full facepiece and operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator with a full face piece and operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode. Escape: Any air-purifying full facepiece respirator (gas mask) with a chin-style or front- or back-mounted canister providing protection against the compound of concern. Any appropriate escape-type self-contained breathing apparatus. * OFHZ: METHYLAMINE GASES ... MAY TRAVEL A CONSIDERABLE DISTANCE TO A SOURCE OF IGNITION & FLASH BACK. * EXPL: 5-21% in air * MODERATE FROM SPARKS OR FLAME. * VAPOR FORMS EXPLOSIVE MIXT WITH AIR. CONTACT WITH MERCURY CAN PRODUCE AN EXPLOSIVE REACTION. * REAC: Incompatibilities: nitromethane * CONTACT WITH MERCURY CAN PRODUCE AN EXPLOSIVE REACTION. * DCMP: When heated to decomp it emits toxic fumes of NOx. * ODRT: THE ODOR OF METHYLAMINE IS FAINT BUT READILY DETECTABLE AT LESS THAN 10 PPM, BECOMES STRONG AT FROM 20 TO 100 PPM AND INTOLERABLY AMMONIACAL AT 100 TO 500 PPM. * Odor recognition in air= 2.10X10-2 ppm (purity not specified) * Low: 0.0252 mg/cu m; High: 12.0 mg/cu m * [R6] SERI: MODERATE IRRITANT TO SKIN, EYES & MUCOUS MEMBRANES ... * EQUP: Wear appropriate clothing to prevent any possibility of skin contact with liquid methylamine. Wear eye protection to prevent any possibility of eye contact. Employees should wash immediately when skin is wet or contaminated. Remove clothing immediately if wet or contaminated to avoid flammability hazard. Provide emergency showers and eye wash. * The following types of respirators should be selected under the prescribed concentrations: 100 ppm: Any self-contained breathing apparatus with a full facepiece. Any supplied-air respirator with a full facepiece. Any chemical cartridge respirator with a full facepiece and cartridge(s) providing protection against the compound of concern. Any air-purifying full facepiece respirator (gas mask) with a chin-style or front- or back-mounted canister providing protection against the compound of concern. Any powered air-purifying respirator with cartridge(s) providing protection against the compound of concern. Emergency or planned entry in unknown concentration or IDLH conditions: Any self-contained breathing apparatus with a full facepiece and operated in a pressure-demand or other positive pressure mode. Any supplied-air respirator with a full face piece and operated in pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode. Escape: Any air-purifying full facepiece respirator (gas mask) with a chin-style or front- or back-mounted canister providing protection against the compound of concern. Any appropriate escape-type self-contained breathing apparatus. * OPRM: Contact lenses should not be worn when working with this chemical. * Contact lens use in industry is controversial. A survey of 100 corporations resulted in the recommendation that each company establish their own contact lens use policy. One presumed hazard of contact lens use is possible chemical entrapment. Many authors found that contact lens minimized injury or protected the eye. The eye was afforded more protection from liquid irritants. The authors concluded that soft contact lens do not worsen corneal damage from strong chemicals and in some cases could actually protect the eye. Overall, the literature supports the wearing of contact lenses in industrial environments as part of the standard eye protection, eg face shields; however, more data are needed to establish the value of contact lenses. * [R7] If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Use water spray to knock-down vapors. Attempt to stop leak if without hazard. /Methylamine, Anhydrous/ * Personnel protection: Avoid breathing vapors. Keep upwind. Wear self-contained breathing apparatus when fighting fires involving this material. Do not handle broken packages without protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Methylamine, anhydrous/ * Evacuation: If material leaking (not on fire), downwind evacuation must be considered. /Methylamine, anhydrous/ * Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be contained with a flexible impermeable membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquids with fly ash, cement powder, sawdust, or commercial sorbents. /Methylamine, anhydrous/ * Environmental considerations: Water spill: Use natural barriers or oil spill controll booms to limit spill motion. Use surface active agent (eg detergent, soaps, alcohols) to compress and thicken spilled material. Inject "universal" gelling agent to solidify encircled spill and increase effectiveness of booms. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates or greater concentration. /Methylamine, anhydrous/ * Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment. /Methylamine, Anhydrous/ * SHIP: Whenever hazardous materials are to be transported, Title 49 CFR, Transportation, Parts 100-180, published by the US Dept of Transportation, contain the regulatory requirements and must be consulted. * [R8] Shipping description: Methylamine, anhydrous, IMO 2.3, UN 1061. Label(s) required: Poison gas, Flammable gas. Acceptable Modes of transportation: Water. Forbidden on passenger or cargo aircraft and passenger railcar. * [R9] Int'l Air Shipments: Shipping description: Methylamine, anhydrous, IMO 2.3, UN 1061. Label(s) required: Flammable gas. Packaging Instructions: cargo; 5.2.200. Forbidden on passenger aircraft. * Water shipments: Shipping description: Methylamine, anhydrous, IMO 2.3, UN 1061. Label(s) required: Flammable gas. * [R10] Shipping description: Methylamine aqueous solution, IMO 3.0, UN 1235. Label(s) required: Flammable liquid. Acceptable Modes of transportation: Air, rail, road, and water. * [R9] Int'l Air Shipments: Shipping description: Methylamine aqueous solution, IMO 3.0, UN 1235. Label(s) required: Flammable liquid. Packaging Instructions: 5.3.305 (passenger); 5.3.307 (cargo). * Water shipments: Shipping description: Methylamine aqueous solution, IMO 3.0, UN 1235. Label(s) required: Flammable liquid. * [R10] STRG: PROTECT AGAINST PHYSICAL DAMAGE. OUTSIDE OR DETACHED STORAGE ... PREFERABLE. INSIDE STORAGE OF LIQ SOLN ... IN A STANDARD FLAMMABLE LIQ STORAGE ROOM OR CABINET. INSURE AGAINST ACCIDENTAL CONTACT WITH MERCURY. INSIDE STORAGE OF GAS ... COOL, WELL-VENTILATED, NONCOMBUSTIBLE LOCATION, AWAY FROM ... SOURCES OF IGNITION. * KEEP WELL CLOSED. /METHYLAMINE HYDROCHLORIDE/ * STORAGE TEMP: AMBIENT * CLUP: Overspread /spill with/ sufficient sodium bisulfate and sprinkle /with/ water. * DEODORIZATION OF AMINE-CONTAINING WASTE GAS FROM FISH PROCESSING PLANTS BY ACTIVATED SLUDGE WAS INVESTIGATED. MONOMETHYLAMINE WAS RAPIDLY ABSORBED & NO RESIDUE WAS DETECTED IN EFFLUENT GAS. * [R11] DISP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. * [R12] Controlled incineration (incinerator is equipped with a scrubber or thermal unit to reduce NOx emissions). * MEDS: Consider ... /resp system, eyes, skin/ in preplacement and periodic physical exam. * HTOX: IRRITATING TO EYES, SKIN, RESPIRATORY TRACT. * ... CASE OF ALLERGIC OR CHEM BRONCHITIS OCCURRED IN A WORKER EXPOSED TO METHYLAMINE. CONCN MEASURED IN WORKROOM RANGED FROM 2-60 PPM. MASKS OR RESPIRATORS WERE WORN DURING GREATEST EXPOSURES. SOME IRRITATION WAS NOTED @ ABOUT 25 PPM. * STIMULATION OF DNA SYNTHESIS IN HUMAN FIBROBLAST CULTURES BY EPIDERMAL GROWTH FACTOR, INSULIN, & SERUM IS INHIBITED BY SOME ALKYLAMINES /INCL METHYLAMINE/ WHEN PRESENT FOR DURATION OF STIMULATORY PREINCUBATION; MITOGENIC ACTIVITIES BLOCKED BY HORMONE-RECEPTOR COMPLEX PROCESSING INHIBITION. * [R13] Brief exposure to 20 to 100 ppm produce transient eye, nose, and throat irritation. No symptoms of irritation are produced from longer exposures at less than 10 ppm. * OLFACTORY FATIGUE OCCURS READILY. BRIEF EXPOSURES TO 20 TO 100 PPM PRODUCE TRANSIENT EYE, NOSE, AND THROAT IRRITATION. NO SYMPTOMS OF IRRITATION ARE PRODUCED FROM LONGER EXPOSURES AT LESS THAN 10 PPM. * NTOX: EYE EFFECT: RABBIT 40% SOLUTION, CORNEAL DAMAGE. SKIN IRRITATION: RABBIT 40% SOLN, 0.1 ML, NECROSIS /FROM TABLE/ * A DOSE OF 0.3-0.4 G ADMINISTERED INTRAVENOUSLY TO RABBITS WAS NOT FATAL. A DOSE OF 2 G ADMINISTERED SUBCUTANEOUSLY WAS ALSO NOT FATAL. /FROM TABLE/ * INCUBATION OF RABBIT RETICULOCYTES WITH METHYLAMINE WAS USED IN ATTEMPT TO INCR INTRACELLULAR PH. TRANSFERRIN-BOUND IRON UPTAKE BY RETICULOCYTES WAS INHIBITED IN A CONCN-DEPENDENT MANNER, BUT A SMALL INCR IN CELLULAR UPTAKE OF TRANSFERRIN WAS PRODUCED. IRON RELEASE FROM TRANSFERRIN APPARENTLY OCCURS AS RESULT OF PROTONATION OF THE TRANSFERRIN WITHIN INTRACELLULAR VESICLES. THUS, IN RABBIT RETICULOCYTES INCUBATED WITH METHYLAMINE, THE METHYLAMINE WOULD INHIBIT IRON RELEASE BY NEUTRALIZING H+ WITHIN THE VESICLES. * [R14] LIQUIFIED METHYLAMINE CAUSED CHANGE IN GUINEA PIG SKIN COLOR WITH SWELLING & PURPLE HUE WITHIN A FEW MINUTES, GRAY & NECROTIC IN 48 HR. AT 12 DAYS FRESH GRANULATION TISSUE HAD APPEARED COVERED BY FLAT EPIDERMIS WITH NO HAIR FOLLICLES. * [R15] A drop of 5% solution in water applied to animal eyes caused hemorrhages in the conjunctiva, superficial corneal opacities, and edema. * Monomethylamine was tested for mutagenicity in the Salmonella/microsome preincubation assay using the standard protocol approved by the National Toxicology Program. Monomethylamine was tested at doses of 0.033, 0.10, 0.33, 1.0, 3.3, and 10 mg/plate in as many as 5 Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98, and TA100) in the presence and absence of rat or hamster liver S-9. Monomethylamine was negative in these tests and the highest ineffective dose tested without toxicity in any S typhimurium strain was 3.3 mg/plate. All cultures at the 10 mg/plate dose exhibited total clearing of the background lawn. * [R16] ADE: METHYLAMINE ... IS NOT OXIDIZED BY AMINE OXIDASES YET IT IS RAPIDLY ABSORBED AND IS NOT EXCRETED IN THE URINE TO ANY APPRECIABLE EXTENT. * A NUMBER OF ALIPHATIC AMINES HAVE BEEN IDENTIFIED AS NORMAL CONSTITUENTS OF MAMMALIAN AND HUMAN URINE. THESE INCLUDE METHYLAMINE ... * Various amines were administered orally in the form of hydrochlorides to study the decomposition mechanisms of these compounds as well as their elimination conditions. The volatile alkyl amine nitrogen was measured daily in the urine. Alkyl amines which were eliminated were isolated as picrolonates and identified by melting point and nitrogen content. Only 1.74% to 1.93% of the administered methylamine was passed in the urine. Up to 32% and 14.9%, respectively, was recovered in the urine following dosing with ethylamine and isobutylamine. Up to 9.5% of administered propylamine was found in the urine and identified as a picrolonate. For dimethylamine and diethylamine, recovery in the urine the following day was 91.5 and 86.2%, respectively. * [R17] METB: mono- and trimethylamines are converted to dimethylamine in the body. * The regulation of methylamine and formaldehyde metabolism in Arthobacter P1 was investigated in carbon-limited continuous cultures. Evidence was obtained that the synthesis of enzymes involved in the conversion of methylamine into formaldehyde and in formaldehyde fixation is induced sequentially in this organism. * [R18] The metabolism of methylamine has been investigated in the rat in order to elucidate the role of monoamine oxidase and intestinal bacteria in the metabolism of the cmpd. In a series of experiments in which short and long acting inhibitors of monoamine oxidase were admin either alone or in combination prior to methyl (14)C amine hydrochloride injection, the excretion of radioactivity in the expired air and the urine was examined to indirectly assess the role of monoamine oxidase in the metabolism of methylamine. * [R19] INTC: COMBINATION OF METHYLAMINE & SODIUM NITRITE INDUCED A HIGHER FREQUENCY OF MUTATIONS THAN THAT CAUSED BY NITRITE ALONE IN ESCHERICHIA COLI. * [R20] 20 MMOL METHYLAMINE TOTALLY ANTAGONIZED THE DIPHTHERIA TOXIN-INDUCED INHIBITION OF PROTEIN FORMATION BY VERO, L, OR FH CELLS, WHEREAS METHYLAMINE ENHANCED THE RICIN-INDUCED INHIBITION OF THE PROTEIN FORMATION. * [R21] PSEUDOMONAS EXOTOXIN (PE) WAS USED AS A PROBE TO STUDY THE MECHANISM BY WHICH PROTEIN LIGANDS ARE INTERNALIZED BY MAMMALIAN CELLS. DATA SUGGEST THAT PE ENTERS CELLS BY RECEPTOR-MEDIATED ENDOCYTOSIS, A PROCESS PREVIOUSLY THOUGHT TO BE RESTRICTED TO THE ENTRY OF BIOLOGICAL SIGNIFICANT MOLECULES SUCH AS LYSOSOMAL ENZYMES AND PEPTIDE HORMONES. METHYLAMINE, AN AGENT KNOWN TO BLOCK THIS PROCESS, PROTECTED MOUSE FIBROBLASTS FROM THE ACTION OF PE. * [R22] DNA was incubated in septum-closed reaction vials with (14)C methylamine and nitrile. The DNA was purified, hydrolyzed with hydrochloric acid, and the purines were analyzed by high pressure liquid chromatography. 7-Methylguanine was detectable as a result of DNA methylation in expt performed in 100 mM acetate at pH 4. Using different concn of amine and nitrite, a first order reaction for total amine and a second order for total nitrite could be shown. A study on the pH dependence using 100 mM malonate buffer, pH 2.0-6.0, revealed a mximum rate at pH 3.5, with steep slopes above and below this pH value. The alkylating agent formed spontaneously by nitrosation and deamination of a primary amine has a long enough lifetime to react with DNA in vitro. * [R23] Young adult male Sprague-Dawley rats were given 30 umol/kg body wt (14)C methylamine hydrochloride and 700 umol/kg body wt sodium nitrite by oral gavage. DNA isolated from the stomach and from the first 15 cm of the small intestine was methylated, containing 7-methylguanine. In a second expt, the excised stomachs were incubated with DNAse before the isolation of the DNA in order to degrade DNA in the lumen and in the uppermost lining cells. This treatment resulted in in a 30% decrease in the yield of DNA and a 90% reduction in the level of 7-methylguanine formation. /Methylamine HCl/ * [R24] ENVS: Methylamine is used in tanning, organic sythesis, dyeing of acetate textiles, paint removers, as an intermediate for accelerators, dyes, pharmaceuticals, insecticides, fungicides, and surface active agents, and as a fuel additive, polymerization inhibitor, photographic developer, and rocket propellent. Methylamine occurs naturally in the urine of dogs after eating meat and in certain plants such as Mentha aquatica and has been detected in a variety of vegetables and other foods. Methylamine released to the surface of soils (dissolved in water) will probably rapidly volatilize. Methylamine that enters soil is not expected to sorb to organic matter and thus is expected to leach rapidly through soil to groundwater. Biodegradation will probably be the most important degradative process. Methylamine released to water will probably volatilize rapidly. Sorption to biota and sediment will not be significant. Biodegradation will probably be the most significant removal process. Hydrolysis of methylamine will not be significant. No information was found on photolysis, but methylamine should not absorb sunlight. Reaction with hydroxyl radicals will be the fastest chemical removal process for methylamine in the atmosphere (half-life 3-22 hours). Dissolution into rain droplets may be the most important physical removal process for methylamine in the atmosphere. Methylamine has been found in various European rivers, in a swamp, and in soil. It has also been found naturally occuring in a variety of foods and ingestion of food containing methylamine should be a significant exposure route for humans. (SRC) * NATS: VOLATILIZATION OF CATTLE WASTE PRODUCED AMMONIA & AMINES. * [R25] Methylamine occurs in urine of dogs after eating meat and in certain plants such as Mentha aquatica(1). It is also found in a variety of vegetables and other foods(2). * [R26] Occurs in herring brine * Known interstellar molecule * ARTS: TOTAL ALIPHATIC AMINE EMISSIONS IN THE EXHAUST OF 17 CARS WHICH WERE DRIVEN ON A CHASSIS DYNAMOMETER USING THE 1975 FTP TEST WERE LESS THAN 2.2 MG/MILE AND THE AVERAGE EMISSION RATE OF MONOMETHYLAMINE WAS 0.3 MG/MILE. * [R27] Methylamine is used in tanning, organic sythesis(1), dyeing of acetate textiles, paint removers, as an intermediate for accelerators, dyes, pharmaceuticals, insecticides, fungicides, and surface active agents, and as a fuel additive, polymerization inhibitor, photographic developer, and rocket propellent(2). * [R28] ... amines from decomposing fish ... /Amines/ * FATE: TERRESTRIAL FATE: Methylamine released to the surface of soils (dissolved in water) will probably volatilize rapidly. Methylamine that enters soil is not expected to sorb strongly to organic matter (estimated Koc is 12)(1,SRC) and thus is expected to leach rapidly through soil to groundwater. Biodegradation will probably be the most important degradative process. Hydrolysis will not be a significant removal process. (SRC) * [R29] AQUATIC FATE: Methylamine released to water will probably volatilize rapidly. Sorption to biota and sediment will not be significant (estimated BCF is 0.22). Biodegradation will probably be the most significant removal process. Hydrolysis will not be a significant removal mechanism for methylamine. No information was found on photolysis, but methylamine should not absorb sunlight. (SRC) * ATMOSPHERIC FATE: Reaction with hydroxyl radicals will be the fastest chemical removal process for methylamine in the atmosphere (half-life from 3-22 hours). Degradation of methylamine by reaction with oxygen atoms and ozone will not be significant when compared to the rapid degradation of methylamine by hydroxyl radicals (half-life of several years versus several hours, respectively). Dissolution into rain droplets may be the most important physical removal process for methylamine in the atmosphere. (SRC) * BIOD: Methylamine biodegradation was 96% in the OECD screening test and 107% in the closed bottle test (aerobic mixed cultures)(1). Pseudomonas sp MA (an aerobe) grew on methylamine as a sole carbon, nitrogen, and energy source(2). Sixteen non-methylotrophic bacteria, including representatives of Arthrobacter, Bacillus, Pseudomonas, and Enterobacteriaceae, were able to grow with methylamine as sole nitrogen source in the presence of a mixture of organic compounds but unable to grow with methylamine as sole carbon source(3). Methylamine may also be biodegraded under anaerobic conditions. Mixed cultures from anaerobic marine sediments(4) and pure cultures of Methanosarcina barkeri(5) degraded methylamine under anaerobic conditions. * [R30] Biological oxygen demand (BOD): 67.8% of theoretical in 13 days * ABIO: A rate constant for aqueous hydroxyl radical reaction with methylamine in water is 1.1X10+7/Mol.SEC at pH 5(1). At a typical aqueous hydroxyl radical concn of 10-7 M(2), methylamine half-life would be 199 years(SRC). Hydrolysis will not be a significant degradative process for methylamine (stable pH 3,5, and 9)(3). Under atmospheric conditions, a rate constant for the reaction of ozone with methylamine is 2.13X10-20 cu cm/mol sec (296 deg K)(4). At a typical average ozone concetration of 1.0X10+12 molecules/cu cm(5), methylamine half-life would be 1.03 years(SRC). A rate constant for the raction of oxygen atoms O(3P) with methylamine in the atmosphere is 0.565X10-12 cu cm/mol sec (298.0 deg K)(6). At a typical average oxygen atom O(3P) concentration of 2.5X104 molecules/cu cm(5), methylamine half-life would be 1.56 years(SRC). Reaction with hydroxyl radicals will be the fastest chemical removal process for methylamine in the atmosphere. A rate constant for the reaction of hydroxyl radicals with methylamine at room temperature is 2.17X10-11 cu cm/mol sec(7,8), resulting in half-lives of 3-22 hours (using hydroxyl radical concentrations of 3X10+6 molecules cu cm(7) and 4.1X10+5 molecules/cu cm(5). * [R31] BIOC: The accumulation ratio for methylamine in mature blade sections of Macrocystis pyrifera ranged from 141 to 183 (methylamine concentrationin the medium ranged from 2.15-8.14 uM)(1). An estimated bioconcentration factor (BCF) for methylamine, using a measured log Kow of -0.57(2) using a recommended regression equation(3) is 0.22(SRC). This indicates that methylamine has an extremely low potential to bioconcentrate(SRC). * [R32] KOC: An estimated soil adsorption coefficient (Koc) for methylamine, using a measured log Kow of -0.57(1) using a recommended regression equation(2), is 12 (SRC). This indicates that methylamine will not strongly adsorb to organic matter in soil or sediment and is expected to readily leach through most soils(SRC). * [R33] VWS: No information was found about the volatilization of methylamine from water or soil. However, a measured Henry's Law constant for a similar compound (ethylamine) is 1.0X10-5(1). This indicates that volatilization from surface waters and from the surface of moist soils should be a significant removal mechanism for methylamine(SRC). * [R34] WATC: Methylamine concentrations in various European rivers ranged from 1-20.6 ug/kg (ppb) and was 6.2 ug/kg in a swamp(1). * [R35] SEDS: Methylamine was found in the soil (loam) of the Moscow (USSR) region at an unspecified concentration(1). * [R36] ATMC: AMINES ARE COMMON AIR CONTAMINANTS. /AMINES/ * IN A PLANT PROCESSING DIMETHYLAMINE THE AMBIENT AIR CONTAINED LESS THAN 36.7 MG/CU M METHYLAMINE DURING 6 AM TO 6 PM PERIOD WITH THE CONCN OSCILLATING DURING THE PERIOD. THE URINE OF WORKERS CONTAINED 1.3-2.48 MG/L OF MONOMETHYLAMINE DURING A 24 HR PERIOD. * [R37] FOOD: Methylamine concentrations (mg/kg) in various West German fresh vegetables were: 12 (spinach), 22.7 (red cabbage), 3.4 (cabbage), 65 (cauliflower), 16.6 (kale), 17.6 (white beet), 3.8 (carrots), 30 (red beet), 42 (large radish), and 6.4 (celery)(1). Other methylamine concentrations (mg/kg) in West German foods were: 26.8 (maize, grains), 37.5 (green salad), 5.6 (apple flesh), 4.5 (apple peel), 12 (Camembert cheese), 3 (Limburger cheese) 27 (coffee extract), 80 (freeze-dried coffee), 16 (freeze-dried coffee), 60 (defatted cocoa), 50 (black tea), 4.5 (barley), 3.7 (hops), and < 0.1 (malt)(1). * [R35] PLNT: Methylamine occurs in certain plants such as Mentha aquatica(1). * [R38] FISH: Methylamine concentrations (mg/kg) in various types of herring were: 2 (Bismarck), 3.4 (salted), and 7 (in oil)(1). Methylamine concentration in cod roe (egg-laden ovary) was 10.3 mg/kg(1). * [R35] RTEX: Monitoring data for methylamine is limited. However, ingestion of contaminated food containing methylamine appears to be a significant exposure route. (SRC) * Inhalation ... skin absorption, eye and skin contact. * SAMP: ANALYTE: ALIPHATIC AMINES; MATRIX: AIR; PROCEDURE: ADSORPTION ON SILICA GEL; ELUTION WITH ACID /ALIPHATIC AMINES/ * Collection by impinger or fritted bubbler ... * Analyte: Methylammmonium ion; Matrix: air; Procedure: adsorption on silica gel, desorption with deionized, distilled water * A sampling and analytical procedure for methyl-, dimethyl-, ethyl-, and diethylamine was developed in order to avoid problems typically encountered in the sampling and analysis of low molecular weight aliphatic amines. Samples are collected with adsorbent tubes containing Amberlite XAD-7 resin coated with the derivatizing reagent, NBD chloride (7-chloro-4-nitrobenzo-2-oxa-1,3-diazole). Analysis is performed by HPLC with the use of a fluorescence and/or UV/visible detector. All four amines can be monitored simultaneously, and neither collection nor storage is affected by humidity. Samples are stable at room temperature for at least two weeks. The methodology has been tested for each amine at sample loadings equivalent to air concn ranges of 0.5 to 30 ppm for a sample volume of 10 liters. The method shows promise for determining other airborne primary and secondary low molecular weight aliphatic amines. * [R41] ALAB: ANALYTE: METHYLAMINE; MATRIX: AIR; RANGE: 0.5-120 MG/CU M IN 100-L AIR SAMPLE; PRECISION: 1-9% (ANALYTICAL) PROCEDURE: GC. * ANALYTE: ALIPHATIC AMINES; MATRIX: AIR; RANGE: 1-2400 MG/CU M IN 10-LITER SAMPLE OF AIR; PROCEDURE: GC. /ALIPHATIC AMINES/ * A METHOD WAS DESCRIBED FOR THE COLLECTION OF MONOMETHYLAMINE FROM AIR AND ITS DETERMINATION BY ION CHROMATOGRAPHY. : AMINES/ OF AIR; PROCEDURE: GC. /ALIPHATIC ANALYTE: ALIPHATIC AMINES; MATRIX: AIR; RANGE: 1-2400 MG/CU M IN 10-LITER SAMPLE * [R42] A METHOD IS DESCRIBED FOR TRAPPING AIRBORNE MONOMETHYLAMINE BY 20/35-MESH ACTIVATED CHARCOAL TRAPS AND SUBSEQUENT GLC ANALYSIS OF COLLECTED SAMPLE USING 0.1 N NAOH AQ SOLN. * [R43] A HIGH PERFORMANCE LIQ CHROMATOGRAPHIC METHOD WAS DEVELOPED FOR THE DETERMINATION OF METHYLAMINE IN FISH AND SHRIMP SAMPLES. * [R44] LEVELS OF THE COMMON SECONDARY AMINES IN SQUID, OCTOPUS AND 17 OTHER SEAFOODS WERE DETERMINED BY HPLC. AMMONIA AND DIMETHYLAMINE WERE FOUND IN ALL OF THE SEAFOODS TESTED AND SOME OF THEM ALSO CONTAINED METHYLAMINE. SQUID AND OCTOPUS CONTAIN UNUSUALLY HIGH LEVELS OF DIMETHYLAMINE AND METHYLAMINE. * [R45] ALIPHATIC AMINES WERE DETERMINED IN OIL-SHALE RETORT WATER BY GC. METHYLAMINE WAS FOUND IN SMALL CONCN. * [R46] Analyte: Methylammmonium ion; Matrix: air; Procedure: ion chromatography/electrolytic conductivity detection; range: 6.24-28.1 mg/cu m; precision: 0.058 * A MIXTURE OF 13 LOWER ALIPHATIC AMINES WERE SEPARATED IN A TENAM-GC COLUMN BY TEMPERATURE PROGRAMMING GAS CHROMATOGRAPHY. PRIMARY AMINES WERE CONVERTED INTO CORRESPONDING SCHIFF BASES BY REACTION WITH BENZALDEHYDE. /ALIPHATIC AMINES/ * [R47]
Analytical Method EPA Method 8260
Molecular FormulaC9H10O/SUB>
Use CHEM INT FOR PHARMACEUTICALS
Consumption Patterns
Apparent ColorClear Liquid
Odor Pleasant Fragrance
Boiling Point xxx DEG C
Melting Point xxx DEG C
Molecular Weight 134.19
Density xxx
Sensitivity Data
Environmental Impact
Environmental Fate TERRESTRIAL FATE: Methylamine released to the surface of soils (dissolved in water) will probably volatilize rapidly. Methylamine that enters soil is not expected to sorb strongly to organic matter (estimated Koc is 12)(1,SRC) and thus is expected to leach rapidly through soil to groundwater. Biodegradation will probably be the most important degradative process. Hydrolysis will not be a significant removal process. (SRC) * [R29] AQUATIC FATE: Methylamine released to water will probably volatilize rapidly. Sorption to biota and sediment will not be significant (estimated BCF is 0.22). Biodegradation will probably be the most significant removal process. Hydrolysis will not be a significant removal mechanism for methylamine. No information was found on photolysis, but methylamine should not absorb sunlight. (SRC) ATMOSPHERIC FATE: Reaction with hydroxyl radicals will be the fastest chemical removal process for methylamine in the atmosphere (half-life from 3-22 hours). Degradation of methylamine by reaction with oxygen atoms and ozone will not be significant when compared to the rapid degradation of methylamine by hydroxyl radicals (half-life of several years versus several hours, respectively). Dissolution into rain droplets may be the most important physical removal process for methylamine in the atmosphere. (SRC)
Drinking Water Impact SURFACE WATER:

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